Documental El origen del hombre y su evolución

Yale researchers map ‘switches’ that shaped the evolution of the human brain

Thousands of genetic “dimmer” switches, regions of DNA known as regulatory elements, were turned up high during human evolution in the developing cerebral cortex, according to new research from the Yale School of Medicine.

Unlike in rhesus monkeys and mice, these switches show increased activity in humans, where they may drive the expression of genes in the cerebral cortex, the region of the brain that is involved in conscious thought and language. This difference may explain why the structure and function of that part of the brain is so unique in humans compared to other mammals.

The research, led by James P. Noonan, Steven K. Reilly, and Jun Yin, is published March 6 in the journal Science.

In addition to creating a rich and detailed catalogue of human-specific changes in gene regulation, Noonan and his colleagues pinpointed several biological processes potentially guided by these regulatory elements that are crucial to human brain development.

“Building a more complex cortex likely involves several things: making more cells, modifying the functions of cortical areas, and changing the connections neurons make with each other. And the regulatory changes we found in humans are associated with those processes,” said Noonan, associate professor of genetics, an investigator with the Kavli Institute for Neuroscience, and senior author of the study. “This likely involves evolutionary modifications to cellular proliferation, cortical patterning, and other developmental processes that are generally well conserved across many species."

Scientists have become adept at comparing the genomes of different species to identify the DNA sequence changes that underlie those differences. But many human genes are very similar to those of other primates, which suggests that changes in the way genes are regulated — in addition to changes in the genes themselves — is what sets human biology apart.

Up to this point, however, it has been very challenging to measure those changes and figure out their impact, especially in the developing brain. The Yale researchers took advantage of new experimental and computational tools to identify active regulatory elements — those DNA sequences that switch genes on or off at specific times and in specific cell types — directly in the human cortex and to study their biological effects.

First, Noonan and his colleagues mapped active regulatory elements in the human genome during the first 12 weeks of cortical development by searching for specific biochemical, or “epigenetic” modifications. They did the same in the developing brains of rhesus monkeys and mice, then compared the three maps to identify those elements that showed greater activity in the developing human brain. They found several thousand regulatory elements that showed increased activity in human.

Next, they wanted to know the biological impact of those regulatory changes. The team turned to BrainSpan, a freely available digital atlas of gene expression in the brain throughout the human lifespan. (BrainSpan was led by Kavli Institute member Nenad Sestan at Yale, with contributions from Noonan and Pasko Rakic, a co-author on this study.) They used those data to identify groups of genes that showed coordinated expression in the cerebral cortex. They then overlaid the regulatory changes they had found with these groups of genes and identified several biological processes associated with a surprisingly high number of regulatory changes in humans.

“While we often think of the human brain as a highly innovative structure, it’s been surprising that so many of these regulatory elements seem to play a role in ancient processes important for building the cortex in all mammals, said first author Steven Reilly. “However, this is often a hallmark of evolution, tinkering with the tools available to produce new features and functions.”

Next, Noonan and colleagues plan to investigate the function of some of the regulatory changes they identified by introducing them into the mouse genome and studying their effects on mouse brain development.

Tomado de: http://news.yale.edu/2015/03/05/yale-researchers-map-switches-shaped-evolution-human-brain

World’s oldest butchery tools gave evolutionary edge to human communication

Two and a half million years ago, our hominin ancestors in the African savanna crafted rocks into shards that could slice apart a dead gazelle, zebra or other game animal. Over the next 700,000 years, this butchering technology spread throughout the continent and, it turns out, came to be a major evolutionary force, according to new research from UC Berkeley, the University of Liverpool and the University of St. Andrews, both in the UK.

Combining the tools of psychology, evolutionary biology and archaeology, scientists have found compelling evidence for the co-evolution of early Stone Age slaughtering tools and our ability to communicate and teach, shedding new light on the power of human culture to shape evolution.

Reported today (Jan.13) in the journal Nature Communications, the study is the largest to date to look at gene-culture co-evolution in the context of prehistoric Oldowan tools, the oldest-known cutting devices. It suggests communication among our earliest ancestors may be more complex than previously thought, with teaching and perhaps even a primitive proto-language occurring some 1.8 million years ago.

“Our findings suggest that stone tools weren’t just a product of human evolution, but actually drove it as well, creating the evolutionary advantage necessary for the development of modern human communication and teaching,” said Thomas Morgan, lead author of the study and a postdoctoral researcher in psychology at UC Berkeley.

Video by Phil Ebiner and Roxanne Makasdjian
“Our data show this process was ongoing two and a half million years ago, which allows us to consider a very drawn-out and gradual evolution of the modern human capacity for language and suggests simple ‘proto-languages’ might be older than we previously thought,” Morgan added.

Morgan and University of Liverpool archaeologist Natalie Uomini arrived at their conclusions by conducting a series of experiments in teaching contemporary humans the art of “Oldowan stone-knapping,” in which butchering “flakes” are created by hammering a hard rock against certain volcanic or glassy rocks, like basalt or flint (see video demonstration above).

Oldowan stone-knapping dates back to the Lower Paleolithic period in eastern Africa, and remained largely unchanged for 700,000 years until more sophisticated Acheulean hand-axes and cleavers, which marked the next generation of stone tool technology, came on the scene. It was practiced by some of our earliest ancestors, such as Homo habilis and the even olderAustralopithecus garhi, who walked on two legs, but whose facial features and brain size were closer to those of apes.

In testing five different ways to convey Oldowan stone-knapping skills to more than 180 college students, the researchers found that the demonstration that used spoken communication – versus imitation, non-verbal presentations or gestures – yielded the highest volume and quality of flakes in the least amount of time and with the least waste.

To measure the rate of transmission of the ancient butchery technology, and establish whether more complex communication such as language would get the best results, study volunteers were divided into five- or 10-member “learning chains.” The head of the chain received a knapping demonstration, the raw materials and five minutes to try their hand at it. That person then showed it to the next person in the chain, who in turn showed the next person, and so on. Their competence picked up significantly with verbal instruction.

“If someone is trying to learn a skill that has lots of subtlety to it, it helps to engage with a teacher and have them correct you,” Morgan said. “You learn so much faster when someone is telling you what to do.”

As for what the results mean for the Oldowan hominins: “They were probably not talking,” Morgan said. “These tools are the only tools they made for 700,000 years. So if people had language, they would have learned faster and developed newer technologies more rapidly.”

Without language, one can assume that a hominin version of, say, Steve Jobs would have been hard-pressed to pass on visionary ideas. Still, the seeds of language, teaching and learning were planted due to the demand for Oldowan tools, the study suggests, and at some point hominins got better at communicating, hence the advent of Acheulean hand-axes and cleavers some 1.7 million years ago.

“To sustain Acheulean technology, there must have been some kind of teaching, and maybe even a kind of language, going on, even just a simple proto-language using sounds or gestures for ‘yes’ or ‘no,’ or ‘here’ or ‘there,’” Morgan said.

Indeed, the data suggest that when the Oldowan stone-tool industry started, it was most likely not being taught, but communication methods to teach it were developed later.

“At some point they reached a threshold level of communication that allowed Acheulean hand axes to start being taught and spread around successfully and that almost certainly involved some sort of teaching and proto-type language,” Morgan said.

In addition to Morgan and Uomini, co-authors and researchers on the paper are Luke E. Rendell, Sally E. Street, Hannah M. Lewis, Catherine P. Cross, Cara Evans, Ronan Kearney, Andrew Whiten and Kevin N. Laland, all at the University of St. Andrews in Scotland, Ignacio de la Torre at University College London and Laura Chouinard-Thuly at McGill University in Canada.

Tomado de: http://newscenter.berkeley.edu/2015/01/13/stone-age-tools/

Oldest ever engraving discovered on 500,000-year-old shell

Homo erectus on Java was already using shells of freshwater mussels as tools half a million years ago, and as a 'canvas' for an engraving. The discovery of an engraved geometrical pattern on one of the shells came as a total surprise. The zig zag pattern, that can only be seen with oblique lighting, is clearly older than the weathering processes on the shell arising from fossilization.



Homo erectus on Java was already using shells of freshwater mussels as tools half a million years ago, and as a 'canvas' for an engraving. An international team of researchers, led by Leiden archaeologist José Joordens, published this discovery on 3 December in Nature. The discovery provides new insights into the evolution of human behaviour.

Not only Homo sapiens made engravings

"Until this discovery, it was assumed that comparable engravings were only made by modern humans (Homo sapiens) in Africa, starting about 100,000 years ago," says lead author José Joordens, researcher at the Faculty of Archaeology at Leiden University.

A team of 21 researchers studied hundreds of fossil shells and associated finds and sediments from the Homo erectus site Trinil, on the Indonesian island of Java. The shells are part of the Dubois Collection that has been held at the Naturalis Biodiversity Center since the end of the 19th century. The shells were excavated by the Dutch physician and researcher Eugène Dubois, the discoverer of Pithecanthropus erectus -- now known as Homo erectus.

Engravings older than weathering

The discovery of an engraved geometrical pattern on one of the shells came as a total surprise. The zig zag pattern, that can only be seen with oblique lighting, is clearly older than the weathering processes on the shell arising from fossilisation. The study has excluded the possibility that the pattern could have been caused by animals or by natural weathering processes and shows that the 'zigzag' pattern is the work of Homo erectus.

Five hundred thousand years old

By applying two dating methods, researchers at the VU University Amsterdam and Wageningen University have determined that the shell with the engraving is minimally 430,000 and maximally 540,000 years old.This means that the engraving is at least four times older than the previously oldest known engravings, found in Africa.

Purpose or meaning of the engraving?

"It's fantastic that this engraved shell has been discovered in a museum collection where it has been held for more than a hundred years. I can imagine people may be wondering whether this can be seen as a form of early art," says Wil Roebroeks, Professor of Palaeolithic Archaeology at Leiden University. He was able to finance this long-term research with his NWO Spinoza Prize. "At the moment we have no clue about the meaning or purpose of this engraving."

Early human-like mussel collector

This research has shown that these early human-like people were very clever about how they opened these large freshwater mussels; they drilled a hole through the shell using a sharp object, possibly a shark's tooth, exactly at the point where the muscle is attached that keeps the shell closed. "The precision with which these early humans worked indicates great dexterity and detailed knowledge of mollusc anatomy," says Frank Wesselingh, a researcher and expert on fossil shells at Naturalis. The molluscs were eaten and the empty shells were used to manufacture tools, such as knives.

Possible follow-on research

This discovery from the historical Dubois collection sheds unexpected new light on the skills and behaviour of Homo erectus, and indicates that Asia is a promising and, so far, relatively unexplored area for finding intriguing artefacts.

From the Netherlands, researchers at Leiden University, the Naturalis Biodiversity Center, the Vrije Universiteit Amsterdam, the universities of Wageningen and Delft and the Cultural Heritage Agency of the Netherlands were involved in the research.

This research is being financed by research funding from the NWO Spinoza Prize.

Tomado de: http://www.sciencedaily.com/releases/2014/12/141203142453.htm

Artículo completo: Homo erectus at Trinil on Java used shells for tool production and engraving